SPECIFIC APPLICATIONS | PHARMACEUTICAL
EVAPORATIVE COOLING APPLICATIONS - PHARMACEUTICAL
- The majority of pharmaceutical products fall into a category which states ‘do not store above 25°C’.
- Pharmaceutical Wholesalers are licensed by the MHRA – the Medicines and Healthcare products Regulatory Agency
- The MHRA audit licensed warehouses who must demonstrate compliance

- Temperature compliance is set by two criteria:
- Mean Kinetic Temperature over a 7 day period must not exceed 25°C
- Absolute maximum temperature shall never exceed 30°C
- Mean Kinetic temperature is a logarithmic calculation which provides a weighted average using the Arrhenius equation

- Most pharmaceutical warehouses use ventilation to keep products cool as refrigeration is prohibitively expensive
- Ventilation cannot maintain compliance with MHRA criteria during prolonged periods of high temperature
- Evaporative cooling can, if correctly specified, ensure full compliance
The chart below shows a typical warehouse using ventilation during 2003 weather conditions

It can be seen that a ventilated system would have ‘excursions’ over 30°C and a MKT over 25°C

An evaporatively cooled warehouse would be fully compliant even during record breaking weather conditions





Merck
Chemilines
installations have also been completed for the following companies